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アイテム
Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary
https://n-seiryo.repo.nii.ac.jp/records/1702
https://n-seiryo.repo.nii.ac.jp/records/17023e1247f8-fe6f-4bd5-ba98-c2cd89634e39
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nsu2018018.pdf (712.8 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-08-30 | |||||
| タイトル | ||||||
| タイトル | Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Gallbladder | |||||
| キーワード | ||||||
| 主題 | Gallbladder Neoplasms | |||||
| キーワード | ||||||
| 主題 | K-ras | |||||
| キーワード | ||||||
| 主題 | Microsatellite instability | |||||
| キーワード | ||||||
| 主題 | p53 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Nagahashi, Masayuki
× Nagahashi, Masayuki× Ajioka, Yoichi× Lang, Istvan× Szentirmay, Zoltan× Kasler, Miklos× Nakadaira, Hiroto× Yokoyama, Naoyuki× Watanabe, Gen× Nishikura, Ken× Wakai, Toshifumi× Shirai, Yoshio× Hatakeyama, Katsuyoshi× Yamamoto, Masaharu |
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| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary.\nMETHODS: We examined 42 cases of gallbladder\ncarcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent dye-labeled\nPCR amplifications of five-microsatellite markers (BAT-25 , BAT-26 , D2S123, D5S346, and D17S250).\nRESULTS: Mutations of p53 were detected in 11 of 22 Japanese cases and 6 of 18 Hungarian cases (11/22 vs 6/18, P = 0.348). Transition at CpG sites was found in none of 11 Japanese cases and 2 of 6 Hungarian cases;\nthe difference was marginally significant (0/11 vs 2/6, P = 0.110). K-ras mutations were detected in only one of the Hungarian cases. Eight of 19 (42.1%) Japanese cases were MSI-high (presence of novel peaks in more than one of the five loci analyzed), whereas only 1 of 15 (6.7%) Hungarian cases was MSI-high (P = 0.047).\nCONCLUSION: It appears that the p53 mutations and MSI differ in patients with gallbladder carcinoma between two distinct high-incidence areas. Geographic variation might exist in the process of gallbladder carcinogenesis. | |||||
| 書誌情報 |
en : World journal of gastroenterology 巻 14, 号 1, p. 70-75, 発行日 2008-01 |
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| 出版者 | ||||||
| 出版者 | WJG Press | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1007-9327 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11690631 | |||||
| フォーマット | ||||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
